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Pharmahub

LyoCalculator

Predicts product temperature during primary freeze-drying based on pseudo steady-state heat and mass transfer model. INPUT PARAMETERS:Fill volume Solids concentration Shelf heat transfer coefficient parameters: Kv=Kc+Kp*Pc/(1+KD*Pc), where Pc is the chamber pressure Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thickness of dry layer at any time Shelf temperature Chamber pressure OUTPUT… Launch Tool
  • Resource Tools
Pharmahub

Dr. Michael Pikal presentation "Modeling in Freeze-Drying:Past, Current State and Future Perspectives"

Early Work by Marcus KarelMotivation for Modeling StudiesStead State ModelsThe Non-Steady State Model in Two DimensionsNon-Steady Models for Sublimation and Desorption DryingThe Nonsteady State Modeling of Freeze Drying: In-Process Product Temperature and Moisture Content Mapping and Pharmaceutical …
  • Resource Online Presentations
MCRN

Extending the square root method to account for model noise in the ensemble Kalman filter

Presented by Patrick Raanes on 2-18-2015 Abstract:A novel approach to account for model noise in the forecast step of the Ensemble Kalman filter (EnKF) is proposed. The core method is based on the approach of the analysis step of ensemble square root filters (ETKF), and consists in right-multiplying…
  • Resource Presentations
  • Resource Notes
Pharmahub

Lyophilization in Review 2019

Summary: In 2019, the U.S. FDA approved a total of 47 lyophilized drug applications submitted by 37 companies. Information on generic drugs was compiled from FDA’s Orange Book database, not including drugs listed with any of the following conditions: discontinued, solution dosage form, routes of inh…
  • Resource Publications
Pharmahub

Freezing Step in the Lyophilization Cycle Development and its Impact on the Product Stability and Overall Formulation

Impact of Freezing step on the lyophilization cycle development has been described. This presentation was delivered in Lyotalk 2016, Mumbai, India Impact of Freezing step on the lyophilization cycle development has been described. This presentation was delivered in Lyotalk 2016, Mumbai, India …
  • Resource Downloads
Pharmahub

Jos Corver lecture on Continuous Freeze Drying

Jos Corver December 2018 lecture on Continuous Freeze Drying for LyoHUB at Purdue University can be viewed at http://www.kaltura.com/tiny/z0puf ABSTRACT:The guidelines of FDA’s PAT mention the need for continuous processing in pharma to achieve a mechanism of 100% control of process and product qual…
  • Resource Online Presentations
Pharmahub

Lyophylcalc

…-state heat and mass transfer modelINPUT PARAMETERS: Fill volume (V), Solids concentration (c), Shelf heat transfer coefficient (Tsh), Cross sectional area of the product in the vial (Ap), Vial area calculated based on outside diameter (Av), Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thiskness of dry layer at any time Shelf temperature, Chamber pressure (Pch)OUTPUT: Product temperature versus time chart,  Product pressure versus time chart, Sublimation rate versus time chart, Dried layer thickness versus time chart  LyoCalculator Launch Tool
  • Resource Tools
Pharmahub

Alina Alexeenko presentation "Heat and Mass Transfer in Spray Freeze Drying" slides

Power Point slides from Alina Alexeenko's presentation "Heat and Mass Transfer in Spray Freeze Drying" presented at 2016 CPPR Freeze Drying Conference in Breckenridge, CO Power Point slides from Alina Alexeenko's presentation "Heat and Mass Transfer in Spray Freeze Drying" presented at 2016…
  • Resource Notes
Pharmahub

LyoHUB Membership PowerPoint

LyoHUB presentation on Who we are and Benefits of Joining this consortium LyoHUB presentation on Who we are and Benefits of Joining this consortium …
  • Resource Online Presentations

Debug Console

Close4 MBRequestSessionTimelineDatabase36Events15
$_GET
Array( terms => *, tags => lyophilization ) Array(
terms => *,
tags => lyophilization
)
$_POST
Array( ) Array(

)
$_COOKIE
Array( ) Array(

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REQUEST_TIME => 1597331750,
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4 MB

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  • onAfterInitialise Method plgSystemXFeed::onAfterInitialise /core/plugins/system/xfeed/xfeed.php:46
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  • onAfterRoute Method plgSystemIncomplete::onAfterRoute /core/plugins/system/incomplete/incomplete.php:46
  • onAfterRoute Method plgSystemUnapproved::onAfterRoute /core/plugins/system/unapproved/unapproved.php:46
  • onAfterRoute Method plgSystemPassword::onAfterRoute /core/plugins/system/password/password.php:46
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