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LyoCalculator

Predicts product temperature during primary freeze-drying based on pseudo steady-state heat and mass transfer model. INPUT PARAMETERS:Fill volume Solids concentration Shelf heat transfer coefficient parameters: Kv=Kc+Kp*Pc/(1+KD*Pc), where Pc is the chamber pressure Cross sectional area of the product in the vial Vial area calculated based on outside diameter Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thickness of dry layer at any time Shelf temperature Chamber pressure OUTPUT… Launch Tool
  • Resource Tools
Pharmahub

Fundamentals of Freeze Drying I: Introduction and Process Overview

OutlineIntroductionAdvantages and limitations of freeze dryingProduct quality attributesProcess overviewFreezingPrimary dryingSecondary drying Outline Introduction Advantages and limitations of freeze drying Product quality attributes Process overview Freezing Primary drying Secondary drying The Fre…
  • Resource Online Presentations
MCRN

Extending the square root method to account for model noise in the ensemble Kalman filter

Presented by Patrick Raanes on 2-18-2015 Abstract:A novel approach to account for model noise in the forecast step of the Ensemble Kalman filter (EnKF) is proposed. The core method is based on the approach of the analysis step of ensemble square root filters (ETKF), and consists in right-multiplying…
  • Resource Presentations
Pharmahub

Fundamentals of Freeze Drying II: The Freezing Process

OutlineThe Freezing ProcessSupercooling and ice nucleationCharacterization of freezing behaviorEstablishment of upper product temperature limit during primary drying …
  • Resource Online Presentations
Pharmahub

Fundamentals of Freeze Drying III: Primary and Secondary Drying

OutlinePrimary dryingHeat transfer considerationsMeasurement of the vial heat transfer coefficientMass transfer considerationsMeasurement of the resistance of the dried product layerSecondary dryingCritical process variables during secondary dryingHow dry is “dry enough” …
  • Resource Online Presentations
  • Resource Notes
Pharmahub

Fundamentals of Freeze Drying

Lyo-Hub Summer School Lyo-Hub Summer School …
  • Resource Courses
Pharmahub

Jos Corver lecture on Continuous Freeze Drying

Jos Corver December 2018 lecture on Continuous Freeze Drying for LyoHUB at Purdue University can be viewed at http://www.kaltura.com/tiny/z0puf ABSTRACT:The guidelines of FDA’s PAT mention the need for continuous processing in pharma to achieve a mechanism of 100% control of process and product qual…
  • Resource Online Presentations
Pharmahub

Lyophylcalc

…-state heat and mass transfer modelINPUT PARAMETERS: Fill volume (V), Solids concentration (c), Shelf heat transfer coefficient (Tsh), Cross sectional area of the product in the vial (Ap), Vial area calculated based on outside diameter (Av), Dry layer mass transfer resistance parameters: Rphat=R0+A1*l/(1+A2*l), where l is thiskness of dry layer at any time Shelf temperature, Chamber pressure (Pch)OUTPUT: Product temperature versus time chart,  Product pressure versus time chart, Sublimation rate versus time chart, Dried layer thickness versus time chart  LyoCalculator Launch Tool
  • Resource Tools
Pharmahub

Alina Alexeenko presentation "Heat and Mass Transfer in Spray Freeze Drying" slides

Power Point slides from Alina Alexeenko's presentation "Heat and Mass Transfer in Spray Freeze Drying" presented at 2016 CPPR Freeze Drying Conference in Breckenridge, CO Power Point slides from Alina Alexeenko's presentation "Heat and Mass Transfer in Spray Freeze Drying" presented at 2016…
  • Resource Notes
Pharmahub

LyoHUB Membership PowerPoint

LyoHUB presentation on Who we are and Benefits of Joining this consortium LyoHUB presentation on Who we are and Benefits of Joining this consortium …
  • Resource Online Presentations

Debug Console

Close6 MBRequestSessionTimelineDatabase36Events15
$_GET
Array( terms => *, tags => freezedrying ) Array(
terms => *,
tags => freezedrying
)
$_POST
Array( ) Array(

)
$_COOKIE
Array( ) Array(

)
$_SERVER
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NOMAD_ADDR_hubzero_cms_nginx_hubzero_cms => 10.65.240.170:22375,
NOMAD_JOB_NAME => hubzero-cms,
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NOMAD_DC => aws-us-east-1,
NOMAD_ADDR_hubzero_cms_nginx_hubzero_cms_ssl => 10.65.240.170:23919,
NOMAD_PORT_hubzero_cms_nginx_hubzero_cms_ssl => 23919,
NOMAD_REGION => global,
PATH => /usr/local/sbin:/usr/local/bin:/usr/sbin:/usr/bin:/sbin:/bin,
NOMAD_TASK_NAME => hubzero-cms-php,
NOMAD_SECRETS_DIR => /secrets,
PWD => /var/www/html,
NOMAD_GROUP_NAME => hubzero-cms,
NOMAD_TASK_DIR => /local,
NOMAD_IP_hubzero_cms_nginx_hubzero_cms => 10.65.240.170,
USER => www-data,
HTTP_X_REAL_IP => 3.235.107.209,
HTTP_X_FORWARDED_PROTO => https,
HTTP_X_FORWARDED_PORT => 443,
HTTP_X_FORWARDED_HOST => onescienceplace.org,
HTTP_X_FORWARDED_FOR => 3.235.107.209,
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HTTP_USER_AGENT => CCBot/2.0 (https://commoncrawl.org/faq/),
HTTP_HOST => onescienceplace.org,
REDIRECT_STATUS => 200,
SERVER_PORT => 443,
SERVER_ADDR => 172.17.0.3,
REMOTE_PORT => 49042,
REMOTE_ADDR => 172.17.0.1,
SERVER_SOFTWARE => nginx/1.15.7,
GATEWAY_INTERFACE => CGI/1.1,
HTTPS => on,
REQUEST_SCHEME => https,
SERVER_PROTOCOL => HTTP/1.1,
DOCUMENT_ROOT => /srv/http/_default,
DOCUMENT_URI => /search/,
REQUEST_URI => /search/?terms=*&tags=freezedrying,
SCRIPT_NAME => /search/,
CONTENT_LENGTH => ,
CONTENT_TYPE => ,
REQUEST_METHOD => GET,
QUERY_STRING => terms=*&tags=freezedrying,
SERVER_NAME => ~(?<spoke>^[^\.]*)(\.|)(onescienceplace.org),
SCRIPT_FILENAME => /srv/http/_default/core/index.php,
FCGI_ROLE => RESPONDER,
PHP_SELF => /search/,
REQUEST_TIME_FLOAT => 1597467867.4998,
REQUEST_TIME => 1597467867,
argv => Array(
0 => terms=*&tags=freezedrying
)
,
argc => 1
)
session.client.forwarded 3.235.107.209
separator .
orderBy id
orderDir asc
1 registerIP
2 access
always
renew
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session.token fcceb2299ed121bed661eaa854e94fd8
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6 MB

36 Queries Logged: 0.018236398696899 seconds

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  • onAfterInitialise Method plgSystemHubzero::onAfterInitialise /core/plugins/system/hubzero/hubzero.php:46
  • onAfterInitialise Method plgSystemXFeed::onAfterInitialise /core/plugins/system/xfeed/xfeed.php:46
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  • onAfterRoute Method plgSystemJquery::onAfterRoute /core/plugins/system/jquery/jquery.php:46
  • onAfterRoute Method plgSystemSpamjail::onAfterRoute /core/plugins/system/spamjail/spamjail.php:46
  • onAfterRoute Method plgSystemIncomplete::onAfterRoute /core/plugins/system/incomplete/incomplete.php:46
  • onAfterRoute Method plgSystemUnapproved::onAfterRoute /core/plugins/system/unapproved/unapproved.php:46
  • onAfterRoute Method plgSystemPassword::onAfterRoute /core/plugins/system/password/password.php:46
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